The Little Illini Conference is a high school athletic conference in East Central Illinois that is a member of the Illinois High School Association. A group of small schools near the Indiana border, Little Illini is known for its strong football squads, in particular Casey-Westfield, which has won one state football championship. The conference has undergone significant rearrangement in the past decade with the addition of several larger schools from the Apollo Conference driving many smaller schools to other conferences.
In 2014 several schools, including Cumberland, Palestine-Hutsonville and Oblong left the Little Illini Conference to join the Little Okaw Valley Conference in central Illinois while Paris High School joined the conference. This followed the addition of Newton, Olney and Robinson high schools, which had been longtime members of the Apollo Conference.
Edwards County left the LIC for the Black Diamond Conference in 2016. They became an affiliate member in the BDC for baseball and softball from 2014/2015-2015/2016.
In 2020 Mount Carmel High School announced they would join the conference starting the 2021–22 school year, following the institution of a new playoff system in Illinois and the subsequent collapse of Indiana's Big Eight Conference. While Flora announced they would be departing to the Black Diamond Conference and Red Hill would depart as well.